ABSTRACT
The triterpenoids of Dichrocephala benthamii were investigated by means of silica gel, Sephadex LH-20 and semi-preparative HPLC. Nine triterpenoids were isolated from D. benthamii. By analysis of the EI-MS, NMR spectra and comparison to the data reported in literatures, the structures of these compounds were determined as β-amyrin formiate (1), β-amyrin acetate (2), β-amyrenol (3), β-amyrone (4), 3β-hydroxy-olean-11, 13 (18)-diene (5) , Δ12-oleanene (6) , friedelin (7), dammaradienyl acetate (8), epi-friedeband (9), respectively. Compounds 1-8 were isolated for the first time form this genus, compound 9 was isolated for the first time from this plant, whereas β-amyrin formiate (1) was a new natural product.
Subject(s)
Asteraceae , Chemistry , Triterpenes , ChemistryABSTRACT
OBJECTIVE: To study the chemical constituents of the whole herb of Dichrocephala Benthamii C. B. Clarke. METHODS: The compounds were isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were identified on the basis of spectral analysis and physicochemical characters and confirmed by comparison of their spectral data with those in the literature. RESULTS: Eighteen compounds were isolated and identified respectively as hexadecanoic acid(1), 1-stearin(2), ethyl-stearate(3), tricosanoic acid(4), tetracosanoic acid(5), octacosane(6), dotriacontanic acid(7), 3, 5-dihydroxy-6, 7, 3′, 4′-tetramethoxy flavone(8), chrysosplenetin B(9), oroxylin A(10), apigenin(11), piceol(12), p-hydroxy benzaldehyde(13), aloe-emod-in(14), chrysophanol(15), physcion(16), xanthoxylin(17), and dibutylphthalate(18). CONCLUSION: All the compounds were isolated for the first time from this genus except compound 18. Copyright 2012 by the Chinese Pharmaceutical Association.